The Clarendon Hotel is significant for its association with the National Road, which also serves as St. Clairsville's Main Street.  The 3-story L-shaped commercial building exhibits Romanesque Revival style design and was an important lodging stop for travelers in the 20th century. The building was a nuisance to the city in recent years as the abandoned hotel became the target of graffiti, vandalism, and frequent break-ins. Beginning in 2013, the top two floors were converted to sixteen residential apartments, with retail space occupying the first floor.  The historic lobby, stair, and skylight were carefully renovated to main the interior character.​